- Hypertrophic Cardiomyopathy (HCM)
- Dilated Cardiomyopathy (DCM)
- Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
- Restrictive Cardiomyopathy
- Left Ventricular Non Compaction Cardiomyopathy
- LQT syndrome
- Brugada syndrome
- Catecholaminergic Polymorphic VT (CPVT)
- Prostate cancer diagnosed before age 55
- Colorectal cancer diagnosed before age 50
- Diagnosed with male breast cancer
- Colorectal cancer diagnosed before age 60 AND specific histology ***
- Diagnosis of endometrial OR ovarian cancer
- Multiple bowel polyps (10+)
- Diagnosed before age 50
- Ashkenazi Jewish ancestry
- Breast cancer diagnosed before age 40
- Bowel cancer diagnosed before age 50
- Womb cancer diagnosed before age 50
- 1 FDR† with prostate cancer diagnosed before age 55
- 1 FDR† with prostate cancer at any age
-FDR†/SDR† with endometrial OR colorectal cancer at any age
- Bilateral breast cancer
- Ovarian cancer diagnosis
- Several cancer diagnoses in the same person
- Personal diagnosis of colorectal cancer
- 2+ relatives with colorectal cancer OR endometrial
- 1 FDR†/SDR† with ovarian cancer and 1 FDR/SDR with breast cancer
- 2 FDR with prostate cancer at any age
- 1 FDR with colorectal or endometrial cancer before age 50
1 FDR with LS associated cancer before age 50
2 FDR†/SDR† with LS associated cancers** at any age
3 FDR†/SDR† with LS associated cancers** at any age
1 FDR with colorectal cancer diagnosed before age 50
1 FDR with colorectal cancer diagnosed before age 60 AND specific pathology ***
1 FDR with multiple bowel polyps (10+)
2 FDR with LS associated cancers, one diagnosed before 50
- Relative with breast or ovarian cancer AND Ashkenazi Jewish ancestry
- Diagnosed < age 50 AND triple negative
- Known BRCA mutation
- Significant family history
- 2+ relatives diagnosed with breast cancer
- 1 FDR† with ovarian cancer
- Relative with male breast cancer
- 3 FDR/SDR† with prostate cancer at any age
- 1 FDR/SDR with prostate cancer at any age and Ashkenazi Jewish ancestry
- 1 FDR/SDR with prostate cancer AND:
- 1 FDR/SDR with prostate cancer AND 1 FDR/SDR with:
- 1 FDR/SDR with:
† FDR = first degree relative: brother, father, sister, mother, child
† SDR = second degree relative: aunt, uncle, grandparent, grandchild, niece, nephew
** Colorectal, endometrial, stomach, ovarian, pancreas, ureter and renal pelvis, biliary tract, and brain (usually glioblastoma as seen in Turcot syndrome) tumors, sebaceous gland adenomas and keratoacanthomas in Muir-Torre syndrome, and carcinoma of the small bowel
*** Presence of tumor infiltrating lymphocytes, Crohn’s-like lymphocytic reaction, mucinous/signet-ring differentiation, or medullary growth pattern
