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ProstateGene - Genetic testing for prostate cancer

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Download the ProstateGene brochure

ProstateGene looks at 11 genes which cause
an increased risk of prostate cancer.
The following genes are tested:

ProstateGene is a genetic test for prostate cancer which examines the DNA code for 11 genes known to cause an increased risk of prostate cancer. It is performed on a blood sample and if possible, it is more informative to test a relative who has had prostate cancer first.

What is hereditary Prostate cancer?

Prostate cancer is the most common cancer among men in the UK. Unfortunately, 1 in 8 men will be diagnosed with prostate cancer, with 75% being diagnosed over the age of 65. The majority of prostate cancer occurs by chance however approximately 5-9% of all prostate cancer and 12% of metastatic prostate cancer is estimated to be hereditary. Prostate cancer is very common in older men, is frequently slow growing and even untreated would often not shorten a man’s life. However, in some men prostate cancer is more aggressive and develops faster, in these situations early diagnosis and treatment will save lives. In some families, with hereditary prostate cancer, it may be possible to find the genetic change (mutation) which is responsible for the cancers thereby allowing appropriate cancer screening. In general, men with one first degree relative (father or brother) have twice the risk of prostate cancer, while men with two first degree relatives have five times the risk compared to the general population.

How do I know if I am at risk?

You may be at increased risk of prostate cancer if you have any of the following signs in your family:

  • Early onset prostate cancer (diagnosed before age 55)
  • 3 first degree relatives (brother, son, father) diagnosed with prostate cancer
  • Ashkenazi Jewish ancestry and breast, ovarian or prostate cancer
  • Prostate cancer AND two relatives with breast or ovarian cancer
  • Prostate cancer AND male breast cancer or ovarian cancer or bilateral breast cancer
  • Prostate cancer AND early onset bowel or womb cancer (before 50)
  • Prostate cancer AND 2 relatives with bowel or womb cancer               

How can genetic testing help?

Genetic Testing can help determine the risk of cancer within a family and guide appropriate cancer screening. Depending on the specific genetic risk different screening tests can be arranged and risk-reducing strategies can be considered. However, it is important to be aware that even if testing is normal you may still have an increased risk of prostate cancer based on your family history. 

What will the test show?

There are 3 possible results:

  1. A mutation is found in one of the genes which is known to increase the risk of prostate cancer. Increased screening and/or risk- reducing techniques will be recommended.
  2. A genetic variation is found, but whether or not this is the definite cause of cancer is unknown. Screening will be recommended based on the family history.
  3. No mutation is found. It is possible that there may be an undetectable mutation or a mutation in a different gene. Cancer screening may still be beneficial.

What does it mean if I have a mutation?

If you have a mutation this means that you have an increased risk of prostate cancer and possibly other cancers. Your exact risks will depend on which gene mutation has been found. Extra screening and/or risk-reducing strategies will be discussed. It will also be possible to offer predictive testing to other people in your family to see if they also have a mutation.


The cost for ProstateGene is £1500 which includes pre- and post-test counselling.

For more information please contact us.

Book an initial 1 hour consultation for only £150 and find out if you are at risk

Book your consultation now

Insurance and financial information

Some individuals may be concerned about difficulties obtaining insurance coverage following genetic testing. This does not need to be a concern as the Code on Genetic Testing and Insurance ensures that individuals do not have to disclose cancer predictive test results. More information can be found at https://www.abi.org.uk/globalassets/files/publications/public/genetics/code-on-genetic-testing-and-insurance_embargoed.pdf

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