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ProstateGene - Genetic testing for prostate cancer

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ProstateGene looks at 11 genes which cause an increased risk of prostate cancer. 

The following genes are tested:

ProstateGene is a genetic test for people diagnosed with prostate cancer which examines the DNA code for 11 genes known to cause an increased risk of prostate cancer. It is performed on a blood sample and results take 3-4 weeks. 

What is hereditary Prostate cancer?

Prostate cancer is the most common cancer among men in the UK. Unfortunately, 1 in 8 men will be diagnosed with prostate cancer, with 75% being diagnosed over the age of 65. The majority of prostate cancer occurs by chance however approximately 5-9% of all prostate cancer and 12% of metastatic prostate cancer is estimated to be hereditary. Prostate cancer is very common in older men, is frequently slow growing and even untreated would often not shorten a man’s life. However, in some men prostate cancer is more aggressive and develops faster, in these situations early diagnosis and treatment will save lives. In some families, with hereditary prostate cancer, it may be possible to find the genetic change (mutation) which is responsible for the cancers thereby allowing appropriate cancer screening. In general, men with one first degree relative (father or brother) have twice the risk of prostate cancer, while men with two first degree relatives have five times the risk compared to the general population.

How do I know if I am at risk?

You may be at risk of hereditary prostate cancer if you have prostate cancer AND any of the following signs:

  • Early onset prostate cancer (diagnosed before age 55)
  • Ashkenazi Jewish ancestry 
  • Two relatives with breast or ovarian cancer
  • One relative with male breast cancer or ovarian cancer or bilateral breast cancer
  • One relative with early onset bowel or womb cancer (before 50)
  • Two relatives with bowel or womb cancer               

How can genetic testing help?

Genetic Testing can help determine the cause of the prostate cancer and may suggest particular cancer treatment, in particular, chemotherapy.  Genetic testing can also determine the risk of cancer within a family and guide appropriate cancer screening. Depending on the specific genetic risk different screening tests can be arranged and risk-reducing strategies can be considered. 

What will the test show?

There are three possible results:

  1. A mutation is found in one of the genes which is known to increase the risk of prostate cancer. Different chemotherapy may be indicated. Increased screening and/or risk- reducing techniques will be recommended.
  2. A genetic variation is found, but whether or not this is the definite cause of cancer is unknown. Screening will be recommended based on the family history.
  3. No mutation is found. It is possible that there may be an undetectable mutation or a mutation in a different gene. Cancer screening may still be beneficial.

What does it mean if I have a mutation?

If you have a mutation this explains the diagnosis of prostate cancer and may mean you have an increased risk of other cancers. Your exact risks will depend on which gene mutation has been found. Extra screening and/or risk-reducing strategies will be discussed. It will also be possible to offer predictive testing to other people in your family to see if they also have a mutation.


The cost for ProstateGene is £1400 which includes pre- and post-test counselling.

For more information please contact us.

Book an initial 1 hour consultation for only £150 and find out if you are at risk

Book your consultation now


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